Skip to content

H1N1 (Swine Flu): Wanna Lose Sleep At Night??? Read About Reassortment with H1N1 Pandemic Strain and H5N1 (Bird Flu)

August 7, 2010

The latest Journal of Virology, had an interesting article that has the ability to send chills down your spine…”High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses,” by a group of Japanese and American researchers.

First, what is reassortment? Reassortment is the mixing of the genetic material into new combinations. It is particularly occurs when two similar viruses (think influenza) infect the same cell and exchange genetic material.   Reassortment is responsible for some of the major genetic shifts in the history of the influenza virus. The 1957 and 1968 pandemic influenza strains were caused by reassortment between an avian virus and a human virus.  Our H1N1 pandemic virus was an unusual mix of swine, avian and human influenza genetic material.

A very cool website shows the reassortment process via animation at the cellular level….check it out. http://www.hhmi.org/biointeractive/animations/subunit/sub_middle_frames.htm

So therefore, reassortment is an important mechanism for the evolution of influenza viruses. In this study the researchers co-infected cultured cells with the pandemic swine-origin influenza virus and a contemporary H5N1 virus and found that the two viruses have high genetic compatibility. Studies in human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. Therefore, gulp, the researchers concluded that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.

http://jvi.asm.org/cgi/content/short/JVI.01140-10v1

No comments yet

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: